Immunomodulator potential of Leucas cephalotes Spreng. was investigated on the basis of its leave extract ‘s effect on cellular and humoral immunity. Dried leaves were extracted using successive solvent extraction and extracts were evaluated for their effect on in vitro phagocytosis. Further on the basis of best results in in vitro investigation alcoholic extract was further investigated for its effect on Delayed Type Hypersensitivity (DTH) and hemagglutination titer. Alcoholic extract was found to be safe up to the dose of 2000 mg/kg orally; accordingly 400 mg/kg, 200 mg/kg and 100 mg/kg oral dose was selected as doses for present investigation. At all selected doses effect was found to be immunomodulatory.
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